A headshot will momentarily stun a Witch and further damage can be quickly administered without her being able to retaliate.
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Having a full magazine is necessary to kill most Special Infected.
If you are ensnared at close range, you will have a better chance of hitting it with the Magnum. On Advanced or Expert, you can have a chance to let it grab you at close range because an A.I. But if a player has already been grabbed by its tongue, the Magnum will probably not suffice as all this pistol's accuracy is lost during the vital split second available to a player to get some shots off before being fully snared. If this is so, the Smoker is likely to go down. Against Smokers, the outcome hinges on whether a player was able to aim before it attacked.This is easiest for Hunters, since their natural position is a headfirst prowl.The Magnum is capable of one-hit headshot kills on Smokers, Jockeys and Hunters.The Magnum can kill others with half a magazine, even with just body shots, on all difficulties. Charger, Tank, and Witch), which can take entire magazines of the weapon before falling. The Magnum is not as useful against healthy Special Infected (i.e.Players who are more comfortable using the common Pistol may take some time to adjust to this weapon since it is more akin to an extremely powerful mini-carbine than a Pistol.If you are playing Expert, the Magnum becomes even more useful as you will wish to kill Common Infected as quickly as possible due to their increased strength, but it'd be best to be cautious of hitting your teammates.The Magnum's bullet penetration and fast reload speed is more than enough to keep Common Infected at bay indefinitely, regardless of horde size, so long as they are forced through a narrow passage. The only exception to this is at choke points.Have at least one feasible way to drop a dozen Common Infected at close range before you pick one up. The Magnum has little to no crowd-clearing abilities, especially when surrounded or being attacked.The P220 Pistol is more accurate and has more ammo, making it better overall in this mutation. The Magnum's ability to kill in one hit against Common Infected is removed in the Mutation "Headshot!", so switching to a different secondary would be better due to the small magazine size of the Magnum.This makes it easier to kill Special Infected while incapacitated, allowing you to save teammates that are attacked while attempting to revive you. It also has a much higher DPS than the pistols because of their limited rate of fire.It can easily tear through Common Infected whilst retaining its normal accuracy and rate of fire.